Sodium Carbonate → 4'-Fluoro-2-methoxy-1,1'-biphenyl

HRID 1059253Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1059253
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9].[F:10][C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1.C(=O)([O-])[O-].[Na+].[Na+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:9][O:8][C:3]1[C:2]([C:14]2[CH:15]=[CH:16][C:11]([F:10])=[CH:12][CH:13]=2)=[CH:7][CH:6]=[CH:5][CH:4]=1

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 113582-BromoanisoleHCID 2856454-Fluorophenylboronic acid

Produkt 1

HCID 130895414'-Fluoro-2-methoxy-1,1'-biphenylAusbeute 84,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 178418397HCID 178418397, VerbindungKatalysator

Versuchsvorschrift

By the reaction in the same manner as in Example 4-(ii) using 2-bromoanisole (8.91 g), 4-fluorophenylboronic acid (10.0 g), 2M aqueous sodium carbonate solution (47.6 ml) and tetrakis(triphenylphosphine)palladium(0) (2.20 g), the title compound (8.14 g) was obtained as colorless needle crystals.

Aufarbeitung

  1. customBy the reaction in the same manner as in Example

Quellen und Nachweise

ORD-Eintrag
ord-a689a4a845844721b3654600a706b84d
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06518257B1

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