Ammonia → 10H-Pyrazino[2,3-b][1,4]benzothiazine-8-methanol

HRID 1059303Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1059303
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[S:10][C:11]1[C:16](Cl)=[N:15][CH:14]=[CH:13][N:12]=1)[CH2:5][OH:6].Cl.N>CO>[N:15]1[C:16]2[NH:1][C:2]3[CH:3]=[C:4]([CH2:5][OH:6])[CH:7]=[CH:8][C:9]=3[S:10][C:11]=2[N:12]=[CH:13][CH:14]=1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 235641353-Amino-4-[(3-chloropyrazin-2-yl)thio]benzyl alcohol

Produkt 1

HCID 1094429210H-Pyrazino[2,3-b][1,4]benzothiazine-8-methanolAusbeute 96,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To 1.47 g of 3-amino-4-[(3-chloropyrazin-2-yl)thio]benzyl alcohol were added 20 ml of methanol and 0.45 ml of conc. hydrochloric acid and the resulting mixture was heated under reflux for 30 minutes. Then the reaction mixture was made alkaline by adding ice-water and aqueous ammonia. The precipitate was collected by filtration and dried to thereby give 1.23 g of the title compound as yellow crystals.

Aufarbeitung

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. filtrationThe precipitate was collected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b7887816f108477fa3562fcf3a99e0b5
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06518423B1

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