Hydrochloric Acid → Methyl 1-benzylpiperidine-4-carboximidate dihydrochloride

HRID 1059348

Reaktionsgleichung

Reaktionsgleichung von HRID 1059348
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]#[N:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:16].[CH3:17][OH:18]>>[ClH:16].[ClH:16].[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14](=[NH:15])[O:18][CH3:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 7933831-Benzylpiperidine-4-carbonitrile

Produkt 1

HCID 18670137Methyl 1-benzylpiperidine-4-carboximidate dihydrochloride

Versuchsvorschrift

A solution of 20 g of 1-benzylpiperidine-4-carbonitrile in a mixture of dry dichlolomethane (200 ml) with methanol (30 ml) was cooled and saturated with a hydrogen chloride gas while maintaining the reaction system at 0° C. or below. After allowing to stand for 4 hours at 0° C., the solvent was distilled off under reduced pressure at room temperature or below and the residue was diluted with ethyl acetate. The colorless crystals thus obtained were ground, filtered and washed with ethyl acetate to thereby give 23.6 g of the title compound.

Aufarbeitung

  1. temperaturewhile maintaining the reaction system at 0° C. or below
  2. distillationthe solvent was distilled off under reduced pressure at room temperature or below
  3. additionthe residue was diluted with ethyl acetate
  4. customThe colorless crystals thus obtained
  5. filtrationfiltered
  6. washwashed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-b1a50a6a66eb4d06b1dfd02973992f7f
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06518423B1

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