Ethyl 4-(piperidin-4-yl)-2-methylbutanoate → Ethyl 4-[1-[2-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)ethyl]piperidin-4-yl]-2-methylbutanoate

HRID 1059368Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1059368
CS(O[CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][C:11]2[S:16][C:15]3[N:17]=[CH:18][CH:19]=[N:20][C:14]=3[N:13](COC)[C:12]=2[CH:24]=1)(=O)=O.[NH:25]1[CH2:30][CH2:29][CH:28]([CH2:31][CH2:32][CH:33]([CH3:39])[C:34]([O:36][CH2:37][CH3:38])=[O:35])[CH2:27][CH2:26]1.CC(CC)C([O-])=O>>[N:20]1[C:14]2[NH:13][C:12]3[CH:24]=[C:8]([CH2:7][CH2:6][N:25]4[CH2:30][CH2:29][CH:28]([CH2:31][CH2:32][CH:33]([CH3:39])[C:34]([O:36][CH2:37][CH3:38])=[O:35])[CH2:27][CH2:26]4)[CH:9]=[CH:10][C:11]=3[S:16][C:15]=2[N:17]=[CH:18][CH:19]=1

Komponenten

4

Edukt 3

HCID 11298836Ethyl 4-(piperidin-4-yl)-2-methylbutanoateHCID 186705792-[10-(methoxymethyl)-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl]ethyl methanesulfonateHCID 222532972-Methylbutyrate

Produkt 1

HCID 11476192Ethyl 4-[1-[2-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)ethyl]piperidin-4-yl]-2-methylbutanoate

Versuchsvorschrift

Starting with 2-[10-(methoxymethyl)-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl]ethyl methanesulfonate and ethyl 4-(piperidin-4-yl)-2-methylbutanoate, ethyl 4-[1-[2-10-(methoxymethyl)-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)-ethyl]piperidin-4-yl]-2-methylbutanoate was obtained by the same method as the one of Example 63. Next, this product was treated by the same method as the one of Example 8 to thereby give the title compound.

Aufarbeitung

  1. customwas obtained by the same method as the one of Example 63
  2. additionNext, this product was treated by the same method as the one of Example 8

Quellen und Nachweise

ORD-Eintrag
ord-424e495ea4874f809cd54e17529a9b86
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06518423B1

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