Potassium Hydroxide → 2-(Pyridin-2-ylmethyl)imidazole

HRID 1059390Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1059390
CN(C)S([N:6]1[CH:10]=[CH:9][N:8]=[C:7]1[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=1)(=O)=O.[OH-].[K+]>C(O)C>[N:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][C:7]1[NH:8][CH:9]=[CH:10][N:6]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 18670131HCID 18670131, Verbindung

Produkt 1

HCID 186704242-(Pyridin-2-ylmethyl)imidazoleAusbeute 42,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 0.21 g of N,N-dimethyl[2-(pyridin-2-ylmethyl)imidazol-1-yl]sulfonamide in ethanol (2 ml) was added a 2% aqueous solution (20 ml) of potassium hydroxide and the resulting mixture was heated under reflux for 11 hours. After distilling off the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluted with dichloromethane/methanol) to thereby give 0.053 g of the title compound as a colorless oily substance.

Aufarbeitung

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 11 hours
  3. distillationAfter distilling off the solvent under reduced pressure
  4. customthe residue was purified by silica gel column chromatography (eluted with dichloromethane/methanol)

Quellen und Nachweise

ORD-Eintrag
ord-ef9312a1c2ec499bbd6e8cedad8f66e4
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06518423B1

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