3,5-Dimethylpyrazole-1-carboxamidine → N-(3-cyanophenyl)-N'-(1-amidinopiperidin-4-yl)cycloheptylurea

HRID 1059527

Reaktionsgleichung

[C:1]([C:3]1[CH:4]=[C:5]([N:9]([CH:19]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[C:10]([NH:12][CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[O:11])[CH:6]=[CH:7][CH:8]=1)#[N:2].CC1C=C(C)[N:29]([C:33](N)=[NH:34])N=1>N1C=CC=CC=1>[C:1]([C:3]1[CH:4]=[C:5]([N:9]([CH:19]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[C:10]([NH:12][CH:13]2[CH2:18][CH2:17][N:16]([C:33](=[NH:29])[NH2:34])[CH2:15][CH2:14]2)=[O:11])[CH:6]=[CH:7][CH:8]=1)#[N:2]

Komponenten

Reaktionsbedingungen

Temperatur: 110 °C

Versuchsvorschrift

N-(3-Cyanophenyl)-N′-(piperidin-4-yl)cycloheptylurea (0.05 g, 0.126 mmol) was dissolved in pyridine (2 ml) and 3,5-dimethylpyrazole-1-carboxamidine (0.037 g, 0.188 mmol) was added under a nitrogen atmosphere. The reaction was heated to 110° C. for 6 h, then was allowed to cool and was concentrated to give a viscous amber oil. The product was purfied by HPLC on a Vydec® C-18 column eluting with solvent mixture A (acetonitrile:water:TFA 80:20:0.3) and solvent mixture B (water:TFA 99.7:0.3) using a gradient starting with A:B at 3:97 and changing to A:B at 70:30 over 15 min. The product eluted at 13.8 minutes was concentrated to give N-(3-cyanophenyl)-N′-(1-amidinopiperidin-4-yl)cycloeptylurea as an amorphous solid (0.036 g); LRMS (M+H)+ m/z 341.

Aufarbeitung

temperatureto cool
concentrationwas concentrated
customto give a viscous amber oil
washeluting with solvent mixture A (acetonitrile:water:TFA 80:20:0.3) and solvent mixture B (water:TFA 99.7:0.3)
customover 15 min
washThe product eluted at 13.8 minutes
concentrationwas concentrated
customto give N-(3-cyanophenyl)-N′-(1-amidinopiperidin-4-yl)cycloeptylurea as an amorphous solid (0.036 g)

Quellen und Nachweise

ORD-Eintrag: ord-a91c782b05a54bb3a4a787bde95babbd
Quelldatensatz: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06521614B1

Verknüpfte Notizen

Wird geladen…