HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trifluoroacetic acid → 5-Amino-2-fluoroisonicotinic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | 5-((tert-Butoxycarbonyl)amino)-2-fluoroisonicotinic acid | HCID 10611065 | — |
| Produkt | 5-Amino-2-fluoroisonicotinic acid | HCID 2762511 | 75,6% |
Reaktionsschritte
Reaction of 5-[N-(tert-butoxycarbonyl)amino]-2-fluoropyridine-4-carboxylic acid (1.0 g, 3.9 mmol) with TFA as described above gives 5-amino-2-fluoropyridine-4-carboxylic acid(0.46 g, 74%). 1H NMR (DMSO) δ 7.85 (1H, d, J=1.5 Hz), 7.23 (1H, d, J=2.5 Hz).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06521620B1 |
| Quelldatensatz | uspto-grants-2003_02 |
| ORD ID | ord-4fe7263a8326468697b13918a4e760e8 |
| Quellennotiz | uspto-grants-2003_02 |