HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Formamide → 6-fluoropyrido[3,4-d]pyrimidin-4-ol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Formamide | HCID 713 | — |
| Edukt | 5-Amino-2-fluoroisonicotinic acid | HCID 2762511 | — |
| Produkt | 6-fluoropyrido[3,4-d]pyrimidin-4-ol | HCID 135417370 | 20% |
Reaktionsschritte
Reaction of 5-amino-2-fluoropyridine-4-carboxylic acid with formamide at 140° C. as above gave 6-fluoro-3H-pyrido[3,4-d]pyrimidin-4-one (˜20%). 1H NMR (DMSO) δ 12.48 (1H, m), 8.74 (1H, s), 8.16 (1H, s), 7.63 (1H, d, J=3 Hz).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06521620B1 |
| Quelldatensatz | uspto-grants-2003_02 |
| ORD ID | ord-b3a50250bbdb442693a580d7d42f2971 |
| Quellennotiz | uspto-grants-2003_02 |