Piperidine → N-(4-Ethoxy-7-piperidin-1-yl-benzothiazol-2-yl)-4-fluoro-benzamide

HRID 1060312Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1060312
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH3:10])=[C:4]([N+:11]([O-])=O)[CH:3]=1.[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1.[F:20][C:21]1[CH:46]=[CH:45][C:24]([C:25]([NH:27][C:28]2[S:29]C3C(N4CCOCC4)=CC=C(OC)C=3N=2)=[O:26])=[CH:23][CH:22]=1>>[CH2:9]([O:8][C:5]1[C:4]2[N:11]=[C:28]([NH:27][C:25](=[O:26])[C:24]3[CH:45]=[CH:46][C:21]([F:20])=[CH:22][CH:23]=3)[S:29][C:3]=2[C:2]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:7][CH:6]=1)[CH3:10]

Komponenten

4

Edukt 3

HCID 8082PiperidineHCID 102002144-fluoro-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamideHCID 222831884-Bromo-1-ethoxy-2-nitrobenzene

Produkt 1

HCID 22283331N-(4-Ethoxy-7-piperidin-1-yl-benzothiazol-2-yl)-4-fluoro-benzamide

Versuchsvorschrift

The title compound was prepared strarting from 4-bromo-1-ethoxy-2-nitro-benzene and piperidine as described for 4-fluoro-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamide (Example 275) and obtained as a yellow solid in 10% overall yield, MS: m/e=400 (M+H+).

Aufarbeitung

  1. customobtained as a yellow solid in 10% overall yield, MS

Quellen und Nachweise

ORD-Eintrag
ord-f8d994a250cb4766a4ee77a0a1acb428
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06521754B2

Notizen zur Reaktion

Wird geladen…