Thiomorpholine → 4-(3,5-Dimethoxybenzyl)thiomorpholine

HRID 1060479Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1060479
[NH:1]1[CH2:6][CH2:5][S:4][CH2:3][CH2:2]1.[CH3:7][O:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([O:17][CH3:18])[CH:16]=1)[CH2:12]Cl>C1COCC1>[CH3:18][O:17][C:15]1[CH:14]=[C:11]([CH2:12][N:1]2[CH2:6][CH2:5][S:4][CH2:3][CH2:2]2)[CH:10]=[C:9]([O:8][CH3:7])[CH:16]=1

Komponenten

4

Edukt 2

HCID 67164ThiomorpholineHCID 27583953,5-Dimethoxybenzyl chloride

Produkt 1

HCID 7560214-(3,5-Dimethoxybenzyl)thiomorpholineAusbeute 73,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Thiomorpholine (3.4 g) was added to a solution of 3,5-dimethoxybenzyl chloride (2 g) in THF (25 mL) and the mixture was stirred overnight at room temperature. The solid material was removed by filtration and the filtrate was evaporated. The residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1/2) to yield 2 g of 3,5-dimethoxy-1-(thiomorpholino-methyl)benzene. ESMS: m/z 253 (M).

Aufarbeitung

  1. customThe solid material was removed by filtration
  2. customthe filtrate was evaporated
  3. customThe residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1/2)

Quellen und Nachweise

ORD-Eintrag
ord-7788b8a933b8460c8415281e474eb93e
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06521666B1

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