Ammonia → (2RS,3S)-3-Amino-2-hydroxy-4-phenylbutyramide

HRID 1061655Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1061655
[NH2:1][C@@H:2]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:3]([OH:10])[C:4](OC(C)C)=[O:5].[NH3:18]>CO>[NH2:1][C@@H:2]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:3]([OH:10])[C:4]([NH2:18])=[O:5]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 11736536isopropyl (2RS,3S)-3-amino-2-hydroxy-4-phenylbutyrate

Produkt 1

HCID 57310726(2RS,3S)-3-Amino-2-hydroxy-4-phenylbutyramide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of isopropyl (2RS,3S)-3-amino-2-hydroxy-4-phenylbutyrate (200 mg, Reference compound No. 4-1) in methanol (3 ml) is saturated with an ammonia gas, and the solution is sealed and stirred overnight. The reaction solution is concentrated under reduced pressure to give the titled reference compound (162 mg).

Aufarbeitung

  1. customthe solution is sealed
  2. concentrationThe reaction solution is concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8aa7d5ce399044a19095ca39e8c1e607
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06960575B2

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