Stannous chloride dihydrate → 5'-Amino-2'-fluorobiphenyl-2-carbonitrile

HRID 1061737Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1061737
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[C:11]1[C:12]([C:17]#[N:18])=[CH:13][CH:14]=[CH:15][CH:16]=1.O.O.[Sn](Cl)Cl>C(O)C.O1CCCC1>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([C:11]2[C:12]([C:17]#[N:18])=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:4]=1

Komponenten

5

Edukt 2

HCID 61436Stannous chloride dihydrateHCID 114478612'-Fluoro-5'-nitrobiphenyl-2-carbonitrile

Produkt 1

HCID 114699075'-Amino-2'-fluorobiphenyl-2-carbonitrileAusbeute 75,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A cooled (0° C.) suspension of 2′-fluoro-5′-nitrobiphenyl-2-carbonitrile (24.2 g, 100 mmol) in ethanol (150 ml) and tetrahydrofuran (150 ml) was treated with tin(II) chloride dihydrate (67.7 g, 300 mmol) and the mixture was stirred to ambient temperature over 12 h. The solvent was removed in vacuo and the residue treated with ice-cold 2N sodium hydroxide (750 ml). The resulting slurry was stirred for 60 min then extracted with dichloromethane (2×400 ml). The organics were combined, washed with water, brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give a red solid. Crystallisation from toluene gave 5′-amino-2′-fluorobiphenyl-2-carbonitrile as a cream-coloured solid (16 g, 75%): δH (400 MHz, CDCl3) 3.65 (2H, br), 6.67-6.73 (2H, m), 7.00 (1H, t, J 9), 7.44-7.49 (2H, m), 7.64 (1H, td, J 9 and 2), 7.75 (1H, dd, J 8 and 2); m/z (ES+) 213 (M++H).

Aufarbeitung

  1. temperatureA cooled
  2. customThe solvent was removed in vacuo
  3. additionthe residue treated with ice-cold 2N sodium hydroxide (750 ml)
  4. stirringThe resulting slurry was stirred for 60 min
  5. extractionthen extracted with dichloromethane (2×400 ml)
  6. washwashed with water, brine
  7. dry with materialdried over anhydrous magnesium sulfate
  8. filtrationfiltered
  9. concentrationconcentrated
  10. customto give a red solid
  11. customCrystallisation from toluene

Quellen und Nachweise

ORD-Eintrag
ord-83c677ebdcf54f04a013114c871ed61e
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06960598B2

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