HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trifluoroacetic acid → 3-[7-(4-Fluoro-phenyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-benzonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | {3-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4'-fluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester | HCID 86588019 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 3-[7-(4-Fluoro-phenyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-benzonitrile | HCID 9798726 | — |
Reaktionsschritte
Prepared from {3-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-4′-fluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example K32) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as an orange solid (141 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06960578B2 |
| Quelldatensatz | uspto-grants-2005_11 |
| ORD ID | ord-3d995de1649941e6acd211179e5c22be |
| Quellennotiz | uspto-grants-2005_11 |