Hydrochloric Acid → 1-(2-Fluoro-ethyl)-[1,4]diazepane

HRID 1062563Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1062563
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([CH2:15][CH2:16][F:17])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:18]>O1CCCC1>[ClH:18].[ClH:18].[F:17][CH2:16][CH2:15][N:11]1[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 222814761-Tert-butoxycarbonyl-4-(2-fluoroethyl)homopiperazine

Produkt 1

HCID 222813171-(2-Fluoro-ethyl)-[1,4]diazepaneAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 1-tert-butoxycarbonyl-4-(2-fluoroethyl)homopiperazine (550 mg, 2.23 mmol) in 10% aqueous hydrochloric acid (2 mL) and tetrahydrofuran (4 mL) was stirred at room temperature for 2 h, and the reaction mixture was evaporated to dryness under vacuum. Resulting residue was triturated from Et2O/MeOH to afford the titled compound (475 mg, 97%) as a white solid.

Aufarbeitung

  1. customthe reaction mixture was evaporated to dryness under vacuum
  2. customResulting residue was triturated from Et2O/MeOH

Quellen und Nachweise

ORD-Eintrag
ord-b37d5a242b594f0dba95ceb4880f5266
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06962911B2

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