Hydrochloric Acid → 4-PHENYL-1-PIPERAZINECARBOTHIOAMIDE

HRID 1062648Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1062648
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([C:13]([NH:15]C(=O)OCC)=[S:14])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[OH-].[Na+]>>[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([C:13](=[S:14])[NH2:15])[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 1518349ETHYL (4-PHENYL-1-PIPERAZINYL)CARBOTHIOYLCARBAMATE

Produkt 1

HCID 20517984-PHENYL-1-PIPERAZINECARBOTHIOAMIDEAusbeute 63 %

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Ethyl (4-phenyl-1-piperazinyl)carbothioylcarbamate (13 g, 44 mmol) was added to conc. hydrochloric acid (44 mL) and the mixture was stirred at 80° C. for 2 h. The reaction mixture was made basic with 8N aqueous sodium hydroxide solution and the crystals were collected by filtration. The crystals were washed with water and dried to give the title compound (6.1 g, yield 63%).

Aufarbeitung

  1. filtrationthe crystals were collected by filtration
  2. washThe crystals were washed with water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-39c6e7e35fd646cc9aeb751855e24757
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06962933B1

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