5-Methylthiophene-2-carbonyl chloride → 5-Methyl-thiophene-2-carboxylic acid [7-(3-dimethylamino-pyrrolidin-1-yl)-4-methoxy-benzothiazol-2-yl]-amide
Reaktionsgleichung
[CH3:1][C:2]1[S:6][C:5]([C:7](Cl)=[O:8])=[CH:4][CH:3]=1.[CH3:10][N:11]([CH3:29])[CH:12]1[CH2:16][CH2:15][N:14]([C:17]2[C:25]3[S:24][C:23]([NH2:26])=[N:22][C:21]=3[C:20]([O:27][CH3:28])=[CH:19][CH:18]=2)[CH2:13]1>>[CH3:10][N:11]([CH3:29])[CH:12]1[CH2:16][CH2:15][N:14]([C:17]2[C:25]3[S:24][C:23]([NH:26][C:7]([C:5]4[S:6][C:2]([CH3:1])=[CH:3][CH:4]=4)=[O:8])=[N:22][C:21]=3[C:20]([O:27][CH3:28])=[CH:19][CH:18]=2)[CH2:13]1Komponenten
3
Versuchsvorschrift
Using 5-methyl-thiophene-2-carbonyl chloride and 7-(3-dimethylamino-pyrrolidin-1-yl)-4-methoxy-benzothiazol-2-yl-amine the title compound was prepared using the general method of example 1 as yellow solid (90%), MS: m/e=417 (M+H+).
Quellen und Nachweise
- ORD-Eintrag
- ord-ac65af347a3146d08db70b8915a9df2d