4-Amino-1-benzyl-3,5-dimethyl-3-ethylpiperidine → 4-Amino-3,5-dimethyl-3-ethylpiperidine
Reaktionsgleichung
[NH2:1][CH:2]1[CH:7]([CH3:8])[CH2:6][N:5](CC2C=CC=CC=2)[CH2:4][C:3]1([CH3:18])[CH2:16][CH3:17]>CO.[H][H].[OH-].[OH-].[Pd+2]>[NH2:1][CH:2]1[CH:7]([CH3:8])[CH2:6][NH:5][CH2:4][C:3]1([CH3:18])[CH2:16][CH3:17]Komponenten
5
Versuchsvorschrift
A mixture of 20% Pd(OH)2 on carbon (0.4 g) and 4-amino-1-benzyl-3,5-dimethyl-3-ethylpiperidine (2.2 g, 8.9 mmol) in methanol (15 ml) was stirred in hydrogen atmosphere (1 atm.) at 60° C. for 10 hr. The catalyst was filtered off, washed with methanol and filtrate was concentrated to dryness to afford 4-amino-3,5-dimethyl-3-ethylpiperidine as a semi solid.
Aufarbeitung
- filtrationThe catalyst was filtered off
- washwashed with methanol and filtrate
- concentrationwas concentrated to dryness
Quellen und Nachweise
- ORD-Eintrag
- ord-62b4dae9d9e4437ba20fb97ab8c32c6f
- Quelldatensatz
- uspto-grants-2005_11
- Patentnummer
- US06964966B2
Notizen zur Reaktion
Wird geladen…