Triethylamine → 4-(6-Bromo-hexyloxy)-piperidine-1-sulfonic acid phenylamide

HRID 1063365Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1063365
Cl.[Br:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.[C:16]1([NH:22][S:23](Cl)(=[O:25])=[O:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C(N(CC)CC)C>C(Cl)Cl>[C:16]1([NH:22][S:23]([N:13]2[CH2:14][CH2:15][CH:10]([O:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][Br:2])[CH2:11][CH2:12]2)(=[O:25])=[O:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 11564615Phenylsulfamoyl chlorideHCID 222794204-(6-Bromo-hexyloxy)-piperidine hydrochloride

Produkt 1

HCID 697845394-(6-Bromo-hexyloxy)-piperidine-1-sulfonic acid phenylamideAusbeute 135,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A solution of 3 g (10 mmol) 4-(6-Bromo-hexyloxy)-piperidine hydrochloride and 3.44 g (18 mmol) of Phenylsulfamoyl chloride in 100 ml dry CH2Cl2 was treated with 6.95 ml (49.9 mmol) of triethylamine. The reaction was stirred for 4 h at RT, diluted with CH2Cl2 and washed with water. The organic phase was dried (MgSO4) and evaporated to yield 5.67 g (quantitative) of 4-(6-Bromo-hexyloxy)-piperidine-1-sulfonic acid phenylamide.

Aufarbeitung

  1. washwashed with water
  2. dry with materialThe organic phase was dried (MgSO4)
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-4270c30b8777490aa456318db1470513
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06964974B2

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