5-Bromo-2,4-dimethoxybenzaldehyde → 5-(3,5-Dimethyl-isoxazol-4-yl)2,4-dimethoxy-benzaldehyde
Reaktionsgleichung
Br[C:2]1[C:3]([O:12][CH3:13])=[CH:4][C:5]([O:10][CH3:11])=[C:6]([CH:9]=1)[CH:7]=[O:8].[CH3:14][C:15]1[C:19](B(O)O)=[C:18]([CH3:23])[O:17][N:16]=1>>[CH3:14][C:15]1[C:19]([C:2]2[C:3]([O:12][CH3:13])=[CH:4][C:5]([O:10][CH3:11])=[C:6]([CH:9]=2)[CH:7]=[O:8])=[C:18]([CH3:23])[O:17][N:16]=1Komponenten
3
Versuchsvorschrift
Ex-33A: 5-(3,5-Dimethyl-isoxazol-4-yl)-2,4-dimethoxy-benzaldehyde was prepared from 5-bromo-2,4-dimethoxybenzaldehyde and 3,5-dimethyl-isoxazole-4-boronic acid in a similar manner as described in Ex-3A, 75% yield. 1H-NMR (CDCl3) δ 10.34 (s, 1H), 7.63 (s, 1H), 6.52 (s, 1H), 4.00 (s, 3H), 3.90 (s, 3H), 2.12 (s, 6H).
Quellen und Nachweise
- ORD-Eintrag
- ord-cae727d29c5142bab06a1ae4493a7906
- Quelldatensatz
- uspto-grants-2006_08