Hydrochloric Acid → (2r)-2-Amino-3-naphthalen-2-yl-n-(6-oxo-2-phenyl-5,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)propanamide hydrochloride

HRID 1064183Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1064183
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C@@H:12]([NH:36]C(=O)OC(C)(C)C)[C:13](=[O:35])[NH:14][C:15]1[CH:16]=[C:17]2[C:33](=[O:34])[NH:32][N:31]=[CH:30][C:19]3=[C:20]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[NH:21][C:22]([CH:23]=1)=[C:18]23.[ClH:44]>O1CCOCC1>[ClH:44].[NH2:36][C@H:12]([CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)[C:13]([NH:14][C:15]1[CH:16]=[C:17]2[C:33](=[O:34])[NH:32][N:31]=[CH:30][C:19]3=[C:20]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[NH:21][C:22]([CH:23]=1)=[C:18]23)=[O:35]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 1361816471,1-Dimethylethyl (1R)-1-(naphthalen-2-ylmethyl)-2-oxo-2-[(6-oxo-2-phenyl-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)amino]ethylcarbamate

Produkt 1

HCID 136401960(2r)-2-Amino-3-naphthalen-2-yl-n-(6-oxo-2-phenyl-5,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)propanamide hydrochlorideAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Preparation of example 176 from the title compound of Example 154 (59 mg, 0.103 mmol) and 4M HCl in dioxane (10 mL) was carried out analogously to Example 91. Isolation, also in an analogous manner afforded the title compound (52 mg, 0.102 mmol) as an orange/yellow powder in 99% yield.

Quellen und Nachweise

ORD-Eintrag
ord-35257bc22433408281f971e75c5239a7
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06967198B2

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