Oxo[3-(2-oxopyrrolidin-1-yl)phenyl]acetaldehyde → 1-{3-[3-(4-Methoxyphenyl)-[1,2,4]triazin-5-yl]phenyl}pyrrolidin-2-one

HRID 1064295

Reaktionsgleichung

Reaktionsgleichung von HRID 1064295
O=[C:2]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH:6]=1)[CH:3]=O.I.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([NH:28][NH2:29])=[NH:27])=[CH:22][CH:21]=1>>[CH3:18][O:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]2[N:28]=[N:29][CH:3]=[C:2]([C:5]3[CH:6]=[C:7]([N:11]4[CH2:15][CH2:14][CH2:13][C:12]4=[O:16])[CH:8]=[CH:9][CH:10]=3)[N:27]=2)=[CH:24][CH:25]=1

Komponenten

3

Edukt 2

HCID 22273606Oxo[3-(2-oxopyrrolidin-1-yl)phenyl]acetaldehydeHCID 178491255HCID 178491255, Verbindung

Produkt 1

HCID 103829821-{3-[3-(4-Methoxyphenyl)-[1,2,4]triazin-5-yl]phenyl}pyrrolidin-2-one

Versuchsvorschrift

Oxo[3-(2-oxopyrrolidin-1-yl)phenyl]acetaldehyde was reacted with 4-methoxybenzenecarboximidic hydrazide hydriodide salt (0.72 g, 2.46 mmol) using the method described in Example 1 to give 1-{3-[3-(4-methoxyphenyl)-[1,2,4]triazin-5-yl]phenyl}pyrrolidin-2-one as a yellow solid (0.47 g): δH (400 MHz, d6-DMSO) 2.09-2.17 (2H, m), 2.57 (2H, t, J 8.0 Hz), 3.88 (3H, s), 3.99 (2H, t, J 7.0 Hz), 7.16-7.21 (2H, m), 7.64 (1H, t, J 8.0 Hz), 7.98-8.01 (1H, m), 8.18 (1H, d, J 8.2 Hz), 8.51-8.55 (2H, m), 8.66 (1H, t, J 1.8 Hz), 9.95 (1H, s); m/z (ES+) 347.

Quellen und Nachweise

ORD-Eintrag
ord-5381c0e16a5647b88b140a7d990d73a3
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06969716B2

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