3-Methylbenzoyl chloride → HCID 11156487, Verbindung

HRID 1064353Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1064353
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:22][C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=1)[C:26](Cl)=[O:27]>N1C=CC=CC=1>[CH3:22][C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=1)[C:26]([N:1]([C:26](=[O:27])[C:25]1[CH:29]=[CH:30][CH:31]=[C:23]([CH3:22])[CH:24]=1)[C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1)=[O:27]

Komponenten

4

Edukt 2

HCID 743753-Methylbenzoyl chlorideHCID 112888282-Amino-3-cyano-4-benzylaminoquinoline

Produkt 1

HCID 11156487HCID 11156487, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To the solution of 5 g of 2-amino-3-cyano-4-benzylaminoquinoline in 30 ml of pyridine 6 ml of 3-methylbenzoyl chloride are dropped, under stirring at 0° C. The reaction mixture is stirred at 80° C. for 8 hour, then it is poured onto 150 ml of ice-water. The precipitate is filtered off, washed twice with 40 ml of water. The resulting white crystalline material is recrystallized from 200 ml of ethanol to give 9.2 g of the title compound, mp.: 234° C.

Aufarbeitung

  1. stirringThe reaction mixture is stirred at 80° C. for 8 hour
  2. filtrationThe precipitate is filtered off
  3. washwashed twice with 40 ml of water
  4. customThe resulting white crystalline material is recrystallized from 200 ml of ethanol

Quellen und Nachweise

ORD-Eintrag
ord-7067f38f0aae444aa9bfe75d70071d65
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06969723B2

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