Valeryl chloride → (4R,5S)-3-(1'-oxopentyl)-4-methyl-5-phenyl-2-oxazolidinone

HRID 1064438Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1064438
C[C@@H]1[C@H](C2C=CC=CC=2)OC(=O)N1.C(Cl)(=O)CCCC.[O:21]=[C:22]([N:27]1[C@@H:31]([CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH2:30][O:29][C:28]1=[O:39])[CH2:23][CH2:24][CH2:25][CH3:26]>>[O:21]=[C:22]([N:27]1[C@H:31]([CH3:30])[C@H:32]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[O:29][C:28]1=[O:39])[CH2:23][CH2:24][CH2:25][CH3:26]

Komponenten

4

Edukt 3

HCID 61186Valeryl chlorideHCID 2733812(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinoneHCID 11391341(S)-4-benzyl-3-pentanoyloxazolidin-2-one

Produkt 1

HCID 12109355(4R,5S)-3-(1'-oxopentyl)-4-methyl-5-phenyl-2-oxazolidinoneAusbeute 84 %

Versuchsvorschrift

(4R,5S)-3-(1′-oxopentyl)-4-methyl-5-phenyl-2-oxazolidinone was synthesized from (4R,5S)-4-methyl-5-phenyl-2-oxazolidinone and valeroyl chloride by the same procedure as (4S)-3-(1′-oxopentyl)-4-benzyl-2-oxazolidinone. The product (29.55 g) was obtained in 84% yield.

Quellen und Nachweise

ORD-Eintrag
ord-df0c7cdab14b4942b5cedb423cbbe246
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06969732B2

Notizen zur Reaktion

Wird geladen…