HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Iodide → (S)-2-ethoxy-3-{4-[2-(4-isopropoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-propionic acid methyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Iodide | HCID 4875 | — |
| Edukt | Cesium carbonate | HCID 10796 | — |
| Edukt | 4-(Chloromethyl)-2-(4-isopropoxyphenyl)-5-methyl-1,3-oxazole | HCID 21974254 | — |
| Edukt | (S)-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid methyl ester | HCID 68616579 | — |
| Produkt | (S)-2-ethoxy-3-{4-[2-(4-isopropoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-propionic acid methyl ester | HCID 69279907 | — |
Reaktionsschritte
In analogy to the procedure described in example 1 f], (2S)-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid methyl ester (example 1 d]) was reacted with 4-chloromethyl-2-(4-isopropoxy-phenyl)-5-methyl-oxazole in the presence of cesium carbonate and potassium iodide to yield (S)-2-ethoxy-3-{4-[2-(4-isopropoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-propionic acid methyl ester as colorless liquid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06969725B2 |
| Quelldatensatz | uspto-grants-2005_11 |
| ORD ID | ord-3fbd1d2ce86845d0be66e6ec38fd7585 |
| Quellennotiz | uspto-grants-2005_11 |