4-(Quinolin-3-yl)piperidin-4-ol → 1-(3-(2-Tert-butylphenoxy)prop-1-yl)-4-hydroxy-4-(quinolin-3-yl)piperidine
Reaktionsgleichung
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH2:12][CH2:13][CH2:14]Cl)([CH3:4])([CH3:3])[CH3:2].[OH:16][C:17]1([C:23]2[CH:24]=[N:25][C:26]3[C:31]([CH:32]=2)=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH2:12][CH2:13][CH2:14][N:20]1[CH2:21][CH2:22][C:17]([OH:16])([C:23]2[CH:24]=[N:25][C:26]3[C:31]([CH:32]=2)=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:18][CH2:19]1)([CH3:4])([CH3:3])[CH3:2]Komponenten
3
Versuchsvorschrift
Beginning with 0.298 gm (1.3 mMol) 3-chloropropyl 2-tert-butylphenyl ether and 0.300 gm (1.3 mMol) 4-hydroxy-4-(quinolin-3-yl)piperidine, 0.212 gm (39%) of the title compound were recovered as a white, waxy solid.
Quellen und Nachweise
- ORD-Eintrag
- ord-6f8e1e14e946475bbcc8fdb505dda2c3
- Quelldatensatz
- uspto-grants-2001_06
- DOI