3-Methylbutan-2-amine--hydrogen chloride (1/1) → HCID 178446295, Verbindung

HRID 1066124

Reaktionsgleichung

Reaktionsgleichung von HRID 1066124
[Cl:1][C:2]1[C:3]([S:15](=[O:18])(=[O:17])[NH2:16])=[CH:4][C:5]2[S:10](=[O:12])(=[O:11])[NH:9][C:8](=O)[NH:7][C:6]=2[CH:14]=1.Cl.[CH3:20][CH:21]([NH2:25])[CH:22]([CH3:24])[CH3:23]>>[Cl:1][C:2]1[C:3]([S:15](=[O:18])(=[O:17])[NH2:16])=[CH:4][C:5]2[S:10](=[O:12])(=[O:11])[N:9]=[C:8]([NH:25][CH:21]([CH3:20])[CH:22]([CH3:24])[CH3:23])[NH:7][C:6]=2[CH:14]=1

Komponenten

3

Edukt 2

HCID 1207933-Methylbutan-2-amine--hydrogen chloride (1/1)HCID 5229312H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-oxo-, 1,1-dioxide

Produkt 1

HCID 178446295HCID 178446295, Verbindung

Versuchsvorschrift

The title compound was prepared from 6-chloro-2,3-dihydro-3-oxo-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide (4.94 g, 15.84 mmol) and 1,2-dimethylpropylamine hydrochloride (8.0 g, 65.0 mmol) by a method analogous to the method described in example 37, except that the product was purified by column chromatography affording 143 mg (2.4%) of pure product; m.p. (DSC) 244° C. (methanol); 1H-NMR (DMSO-d6): δ 0.90 (dd, 6H, CH(CH3)2), 1.11 (d, 3H, NCHCH3), 1.76 (m, 1H, CH(CH3)2), 3.71 (m, 1H, NHCH), 7.34 (br., 1H, NH), 7.41 (br.s, 1H, ArH), 7.80 (br.s, 2H, SO2NH2), 8.18 (s, 1H, ArH), 10.58 (br.s, 1H, NH); MS (FAB): m/e 381/383 (MH+); (C12H17N4Cl1O4S2) calc. C, 37.84; H, 4.50; N, 14.71; found C, 37.66; H, 4.65; N, 14.52.

Aufarbeitung

  1. customwas purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-25372b6635f7471ab97506248ead98b4
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06242443B1

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