N4-Benzoyl-2'-O-nonylcytidine → N4-Benzoyl-5'-O-(dimethoxytrityl)-2'-O-nonylcytidine
Reaktionsgleichung
[C:1]([NH:9][C:10]1[CH:33]=[CH:32][N:13]([C@@H:14]2[O:31][C@H:28]([CH2:29][OH:30])[C@@H:26]([OH:27])[C@H:15]2[O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[C:12](=[O:34])[N:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:35][O:36][C:37]1[C:38]([O:57][CH3:58])=[C:39]([CH:54]=[CH:55][CH:56]=1)[C:40](Cl)([C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1)[C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1>>[C:1]([NH:9][C:10]1[CH:33]=[CH:32][N:13]([C@@H:14]2[O:31][C@H:28]([CH2:29][O:30][C:40]([C:47]3[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=3)([C:41]3[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=3)[C:39]3[CH:54]=[CH:55][CH:56]=[C:37]([O:36][CH3:35])[C:38]=3[O:57][CH3:58])[C@@H:26]([OH:27])[C@H:15]2[O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[C:12](=[O:34])[N:11]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1Komponenten
3
Versuchsvorschrift
N4-Benzoyl-2′-O-nonylcytidine (2.67 g, 0.0056 mol) was treated with dimethoxytrityl chloride (2.0 g, 1.1 eq) as per the procedure of Example 72 to give 4.2 g of pure product. Anal. Calcd. for C46H53N3O8.½H2O: C, 70.39; H, 6.93; N, 5.35. Found: C, 71.20; H, 6.88; N, 5.41.
Quellen und Nachweise
- ORD-Eintrag
- ord-819f7fb493da49e4b3cb218337e622ec
- Quelldatensatz
- uspto-grants-2001_06