Ethyl bromoacetate → HCID 54158312, Verbindung

HRID 1066576Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1066576
Br[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].C(=O)([O-])[O-].[K+].[K+].[OH:14][C:15]1[CH:22]=[C:21]([CH3:23])[C:20]([CH3:24])=[CH:19][C:16]=1[CH:17]=[O:18]>CC(C)=O>[CH:17]([C:16]1[CH:19]=[C:20]([CH3:24])[C:21]([CH3:23])=[CH:22][C:15]=1[O:14][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4])=[O:18]

Komponenten

5

Edukt 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 71720572-hydroxy-4,5-dimethylbenzaldehyde

Produkt 1

HCID 54158312HCID 54158312, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

0.808 ml of ethyl bromoacetate and 1 g of potassium carbonate were added to a solution of 838 mg of 2-hydroxy-4,5-dimethylbenzaldehyde (J.Chem.Soc. (1953) 820) in 150 ml of acetone. The suspension obtained was heated to reflux overnight and then filtered. The filtrate was concentrated. The crude product was isolated by extraction and purified by chromatography on silica gel and yielded 952 mg of ethyl (2-formyl-4,5-dimethyl-phenoxy)-acetate as a pale yellow solid.

Aufarbeitung

  1. customThe suspension obtained
  2. temperaturewas heated
  3. temperatureto reflux overnight
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated
  6. customThe crude product was isolated by extraction
  7. custompurified by chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-68e11cba932548c4a9367cb26c566cb8
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06242644B1

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