Sodium Carbonate → 6-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-3H-benzooxazol-2-one

HRID 1066742Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1066742
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[N:2]1.Br[CH2:17][CH2:18][C:19]1[CH:28]=[CH:27][C:22]2[NH:23][C:24](=[O:26])[O:25][C:21]=2[CH:20]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(C(C)=O)C(C)C>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([N:10]2[CH2:11][CH2:12][N:13]([CH2:17][CH2:18][C:19]3[CH:28]=[CH:27][C:22]4[NH:23][C:24](=[O:26])[O:25][C:21]=4[CH:20]=3)[CH2:14][CH2:15]2)=[N:2]1

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 27721443-(1-Piperazinyl)-1,2-benzisothiazoleHCID 133060876-Bromoethylbenzoxazolone

Produkt 1

HCID 108098036-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-3H-benzooxazol-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7909Methyl Isobutyl KetoneLösungsmittel

Versuchsvorschrift

To a 125 ml round-bottomed flask equipped with condenser were added 4.82 grams (0.022 mol) of N-(3-benzoisothiazolyl)piperazine (prepared according to the procedure given in U.S. Pat. No. 4,411,901), 5.32 grams (0.022 mol) of 6-(2-bromo)ethylbenzoxazolone, 2.33 grams (0.022 mol) of sodium carbonate, and 50 ml of methyl isobutyl ketone. The mixture was refluxed for 18 hours. The reaction was cooled and partitioned between ethyl acetate and water. The ethyl acetate layer was isolated, washed with water and saturated aqueous sodium chloride solution dried over sodium sulfate, and evaporated to an oil. The oil was chromatographed on silica gel using ethyl acetate as eluent, and the product fractions collected and triturated with methylene chloride/isopropyl ether to give a white solid, 1 m.p. 185°-187° C. NMR (CDCl3): 1.7 (bs, 1 H), 2.8 (m, 8H), 3.6 (m, 4H), 6.9-8.0 (m, 7H).

Aufarbeitung

  1. customTo a 125 ml round-bottomed flask equipped with condenser
  2. customprepared
  3. temperatureThe mixture was refluxed for 18 hours
  4. temperatureThe reaction was cooled
  5. custompartitioned between ethyl acetate and water
  6. customThe ethyl acetate layer was isolated
  7. washwashed with water and saturated aqueous sodium chloride solution
  8. dry with materialdried over sodium sulfate
  9. customevaporated to an oil
  10. customThe oil was chromatographed on silica gel
  11. customthe product fractions collected
  12. customtriturated with methylene chloride/isopropyl ether
  13. customto give a white solid, 1 m
  14. custom185°-187° C

Quellen und Nachweise

ORD-Eintrag
ord-d6e1773fe4724956bd54ee63b461a168
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06245766B1

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