Bromopentafluorobenzene → HCID 178505971, Verbindung

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To a diethyl ether solution of isopropyl magnesium bromide, chloropentafluorobenzene was added at 0 to 40° C. under nitrogen with stirring in a period of thirty minutes, such that the isopropyl magnesium bromide was in 1.03 to 1.05 molar excess of the chloropentafluorobenzene. The mixture was stirred at 47 to 53° C.; after 5 to 10 hours, bromopentafluorobenzene was added to react with the excess isopropyl magnesium bromide, and the mixture was stirred at 25° C. for 1 hour. Any excess bromo-pentafluorobenzene was back-titrated in situ with isopropyl magnesium bromide to form more C6F5MgBr. The yield of C6F5MgBr was 96.1%, and 3.9% C6F5Cl remained, as determined by 19F NMR, using C6H5CF3 as a reference; no trace of iPrMgBr was seen with 1H NMR.

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