Ammonia → HCID 16658632, Verbindung

HRID 1067244

Reaktionsgleichung

Reaktionsgleichung von HRID 1067244
Cl[S:2]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([Cl:16])=[CH:10][N:11]=[C:12]2[Cl:15])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[NH3:17]>>[Cl:15][C:12]1[C:13]2[C:8](=[CH:7][CH:6]=[C:5]([S:2](=[O:4])(=[O:3])[NH2:17])[CH:14]=2)[C:9]([Cl:16])=[CH:10][N:11]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 166582941,4-Dichloroisoquinoline-7-sulfonyl chloride

Produkt 1

HCID 16658632HCID 16658632, Verbindung

Versuchsvorschrift

7-chlorosulphonyl-1,4-dichloroisoquinoline (110 mg, 0.37 mmol) was dissolved in a solution of saturated methanolic ammonia (NH3) (10 mL) and the solution stirred at room temperature for 1.5 hours. The solvents were evaporated in vacuo and the residue was azeotroped with CH2Cl2 and then partitioned between EtOAc and water. The organic phase was washed with brine, dried (MgSO4) and evaporated in vacuo to give 1,4-dichloro-7-sulphamoylisoquinoline (98 mg, 0.35 mmol) as a white solid.

Aufarbeitung

  1. customThe solvents were evaporated in vacuo
  2. customthe residue was azeotroped with CH2Cl2
  3. custompartitioned between EtOAc and water
  4. washThe organic phase was washed with brine
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-2cafeccf2f0a4c2499c528193bf31747
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06248738B1

Verknüpfte Notizen

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