Potassium Hydroxide → 2-(Piperidin-4-yl)-1,3-benzothiazole

HRID 1068142Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1068142
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10]1[CH2:15][CH2:14][N:13](C(=O)C)[CH2:12][CH2:11]1.[OH-].[K+]>CO>[NH:13]1[CH2:12][CH2:11][CH:10]([C:2]2[S:1][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[N:3]=2)[CH2:15][CH2:14]1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 92186951-(4-(Benzo[d]thiazol-2-yl)piperidin-1-yl)ethanone

Produkt 1

HCID 14774392-(Piperidin-4-yl)-1,3-benzothiazoleAusbeute 46 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 1.4 g of 1-(4-(benzothiazol-2-yl)piperidin-1-yl)ethanone in 10 mL of MeOH was added 7.5 mL of KOH (45 wt. % solution). After refluxing for 18 hours, the reaction was cooled to room temperature. The mixture was partitioned between EtOAc and water. The organic phase was washed with brine and dried over MgSO4. Concentration under reduced pressure gave 540 mg of the title compound as a solid.

Aufarbeitung

  1. temperatureAfter refluxing for 18 hours
  2. customThe mixture was partitioned between EtOAc and water
  3. washThe organic phase was washed with brine
  4. dry with materialdried over MgSO4
  5. concentrationConcentration under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d0be67bac92b4883aa6f514c01c77427
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06248755B1

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