Triethylamine → 2-Chloro-n-ethyl-n-(1-methylheptyl)-6-(trimethylsilyl)benzamide

HRID 1068299

Reaktionsgleichung

Reaktionsgleichung von HRID 1068299
C(N(CC)CC)C.[Cl:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]([Si:18]([CH3:21])([CH3:20])[CH3:19])[C:10]=1[C:11](Cl)=[O:12].[CH2:22]([NH:24][CH:25]([CH3:32])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[CH3:23]>C1(C)C=CC=CC=1>[Cl:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]([Si:18]([CH3:21])([CH3:20])[CH3:19])[C:10]=1[C:11]([N:24]([CH2:22][CH3:23])[CH:25]([CH3:32])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[O:12]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 5250531-Heptanamine, 1-methyl, N-ethylHCID 151835572-Chloro-6-(trimethylsilyl)benzoyl chloride

Produkt 1

HCID 186301442-Chloro-n-ethyl-n-(1-methylheptyl)-6-(trimethylsilyl)benzamideAusbeute 38 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

Triethylamine (2.02 g, 20 mmol) was added to a mixture of the compound of Example b (2.47 g, 10 mmol) and N-ethyl-N-(1-methylhept-1-yl)amine (3.15 g, 20 mmol) in toluene (25 mL). The reaction was stirred 2.5 h at ambient temperature, then was partitioned between ethyl acetate and dilute citric acid. The organic phase was washed twice with sat aq NaHCO3, followed with brine, then was dried (MgSO4), concentrated, and kugelrohr distilled under vacuum. The fraction which distilled at 157° C. was collected to afford 1.16 g of the title compound as an amber oil, a 38% yield.

Aufarbeitung

  1. customwas partitioned between ethyl acetate and dilute citric acid
  2. washThe organic phase was washed twice with sat aq NaHCO3
  3. dry with materialwas dried (MgSO4)
  4. concentrationconcentrated
  5. distillationkugelrohr distilled under vacuum
  6. distillationThe fraction which distilled at 157° C.
  7. customwas collected

Quellen und Nachweise

ORD-Eintrag
ord-c631e43568ca44cbba54f6f2be5182cb
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06248894B1

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