Hydrochloric Acid → 4-(3-Methylphenyl)-4-hydroxypiperidine hydrochloride

HRID 1068396Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1068396
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=2)([OH:14])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>CCOC(C)=O>[ClH:22].[CH3:21][C:17]1[CH:16]=[C:15]([C:11]2([OH:14])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:20]=[CH:19][CH:18]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 21193300N-t-Butoxycarbonyl-4-(3-methylphenyl)-4-hydroxy piperidine

Produkt 1

HCID 211931674-(3-Methylphenyl)-4-hydroxypiperidine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of N-t-butoxycarbonyl-4-(3-methylphenyl)-4-hydroxy piperidine (0.546 mg, 1.87 mmol) in EtOAc (30 ml) at 0° C. was bubbled gasseous HCl until saturated. After 10 min the solvent was evaporated in vacuo to afford the title compound of sufficient purity to be used in the next step.

Aufarbeitung

  1. customAfter 10 min the solvent was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c632c0d9cb5f40bca51a3f24a84aaf96
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06248756B1

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