HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Chlorobenzylamine → N-[(4-Chlorophenyl)methyl]-8-hydroxy-2-methyl-7-quinolinecarboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Chlorobenzylamine | HCID 66036 | — |
| Edukt | 8-Hydroxy-2-methylquinoline-7-carboxylic acid | HCID 469823 | — |
| Edukt | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Edukt | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | N-[(4-Chlorophenyl)methyl]-8-hydroxy-2-methyl-7-quinolinecarboxamide | HCID 18372652 | 68,7% |
Reaktionsschritte
To a solution of 8-hydroxy-2-methylquinoline-7-carboxylic acid (0.305 g) of Preparation 5 and 4-chlorobenzylamine (0.219 g) in 20 mL DMF is added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.305 g) and 1-hydroxybenzotriazole monohydrate (0.217 g). The mixture is stirred overnight. The solution is then poured into 30 mL ice-water. The resulting solid is collected and dried to yield 0.337 g of the title product as an off-white solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06252080B1 |
| Quelldatensatz | uspto-grants-2001_06 |
| ORD ID | ord-539f9d85c7c84e25abd4a5d7ae3cbca6 |
| Quellennotiz | uspto-grants-2001_06 |