HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Iodooctane → 5-methoxy-2-methyl-1-octyl-1H-indole-3-acetic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Iodooctane | HCID 12380 | — |
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | Ethyl (5-methoxy-2-methyl-1H-indol-3-yl)acetate | HCID 10729163 | — |
| Produkt | 5-methoxy-2-methyl-1-octyl-1H-indole-3-acetic acid ethyl ester | HCID 53772942 | 51,5% |
Reaktionsschritte
Using the procedure described in Example 50, Part A, 2.47 g (0.01 mol) of 5-methoxy-2-methyl-1H-indole-3-acetic acid ethyl ester was reacted with 0.48 g (0.012 mol) of 60% NaH/mineral oil and then 2.17 mL (0.012 mol of iodooctane. The product was chromatographed on silica gel and eluted with 5% EtOAc/toluene to give 1.85 g (51% yield) of 5-methoxy-2-methyl-1-octyl-1H-indole-3-acetic acid ethyl ester as an oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06252084B1 |
| Quelldatensatz | uspto-grants-2001_06 |
| ORD ID | ord-a0b2dd99105f4b3f893c474cfc89ab4b |
| Quellennotiz | uspto-grants-2001_06 |