Furan → HCID 22396537, Verbindung

HRID 1070382

Reaktionsgleichung

Reaktionsgleichung von HRID 1070382
[CH:1]12[O:10][CH:7]([CH2:8][CH2:9]1)[CH:6]1[CH:2]2[C:3](=[O:12])[NH:4][C:5]1=[O:11].C1(=O)[NH:17][C:16](=O)[CH:15]=C1.O1C=CC=C1.BrCC#N>CC(C)=O.CN(C=O)C>[O:12]=[C:3]1[N:4]([CH2:15][C:16]#[N:17])[C:5](=[O:11])[CH:6]2[CH:2]1[CH:1]1[O:10][CH:7]2[CH2:8][CH2:9]1

Komponenten

7

Edukt 4

HCID 8029FuranHCID 10935MaleimideHCID 11534BromoacetonitrileHCID 23972710-Oxa-4-azatricyclo(5.2.1.02,6)decane-3,5-dione

Produkt 1

HCID 22396537HCID 22396537, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Synthesis took place in analogy to Example VI a from 10-oxa-4-azatricyclo[5.2.1.02,6]decane-3,5-dione (obtainable from maleimide and furan from Diels-Alder reaction for example as described by Padwa, A.; Dimitroff, M.; Waterson, A. G.; Wu, T.; J Org Chem 1997, 62, 4088-4096 and subsequent hydrogenation as described by Ansell, M. F.; Caton, M. P. L.; North, P. C.; Tetrahedron Lett. 1982, 23, 2811) and bromoacetonitrile with the exception that acetone was used as solvent in place of DMF. The substance was employed as crude product in the next reaction.

Aufarbeitung

  1. customSynthesis
  2. customfrom Diels-Alder reaction for example
  3. customThe substance was employed as crude product in the next reaction

Quellen und Nachweise

ORD-Eintrag
ord-5397b9d01bdc473a8cd5f7b98554a071
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06903089B1

Verknüpfte Notizen

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