Methyl 3-nitro-5-phenylbenzoate → Methyl 5-amino-[1,1'-biphenyl]-3-carboxylate

Beteiligte Stoffe

Reaktionsschritte

5-Nitro-biphenyl-3-carboxylic acid methyl ester (1.85 g, 7.19 mmol) and 10% Pd/C (0.185 g) in EtOAc (20 mL) were hydrogenated under balloon for 2 h. The catalyst was filtered and the filtrate was concentrated to dryness. The crude 5-amino-biphenyl-3-carboxylic acid methyl ester was a yellow solid and was taken to the next step.

Herkunft & Nachweise