3,4-Dichlorobenzyl chloride → 3,4-dichlorobenzyl-4-piperidone

HRID 1070488Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1070488
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5]Cl.O.Cl.[O:13]=[C:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(N(CC)CC)C>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][N:17]1[CH2:18][CH2:19][C:14](=[O:13])[CH2:15][CH2:16]1

Komponenten

5

Edukt 3

HCID 76093,4-Dichlorobenzyl chlorideHCID 8471TriethylamineHCID 2723901Piperonylamine

Produkt 1

HCID 108487763,4-dichlorobenzyl-4-piperidone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 3,4-dichlorobenzyl chloride (2.8 ml), 4-ketopiperidine hydrochloride monohydrate and triethylamine (8 ml) in dimethylformamide (30 ml) was stirred at room temperature for 20 h. The mixture was partitioned between water and ethyl acetate, the organic layer dried and evaporated under reduced pressure. Purification was by chromatography eluting with 40-50% ethyl acetate/isohexane. Yield 2.1 g.

Aufarbeitung

  1. customThe mixture was partitioned between water and ethyl acetate
  2. customthe organic layer dried
  3. customevaporated under reduced pressure
  4. customPurification
  5. washeluting with 40-50% ethyl acetate/isohexane

Quellen und Nachweise

ORD-Eintrag
ord-659355a251114a28b73fe0c6bc1705bb
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06903085B1

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