Sodium Hydroxide → 2-(Pyrimidin-2-yloxy)acetic acid

HRID 1070518

Reaktionsgleichung

Reaktionsgleichung von HRID 1070518
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[O:7][CH2:8][C:9]([O:11]CC)=[O:10].[OH-].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[O:7][CH2:8][C:9]([OH:11])=[O:10]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 22396258Ethyl 2-pyrimidinyloxyacetate

Produkt 1

HCID 5662722-(Pyrimidin-2-yloxy)acetic acidAusbeute 58,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Ethyl 2-pyrimidinyloxyacetate (1.4 g) was dissolved in ethanol (10 ml). Sodium hydroxide (2M aq) was added and the mixture was stirred for 64 h. The solvent was evaporated and the residue was dissolved in water, filtered and the acidified with concentrated hydrochloric acid. The resulting precipitate was collected and dried to give the subtitle compound (0.698 g).

Aufarbeitung

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in water
  3. filtrationfiltered
  4. customThe resulting precipitate was collected
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-fde72d6116224d3081aa845e2d8ee2c7
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06903085B1

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