4-Chlorobenzylamine → HCID 10159541, Verbindung

HRID 1070645Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1070645
[Al+3].[Cl-].[Cl-].[Cl-].[Cl:5][C:6]1[CH:13]=[CH:12][C:9]([CH2:10][NH2:11])=[CH:8][CH:7]=1.C([O:16][C:17]([C:19]1[C:28](=[O:29])[C:27]2[C:22](=[CH:23][N:24]=[C:25]([CH2:30][N:31]3[CH2:36][CH2:35][O:34][CH2:33][CH2:32]3)[CH:26]=2)[N:21]([CH3:37])[CH:20]=1)=O)C>C1(C)C=CC=CC=1.C(Cl)Cl>[Cl:5][C:6]1[CH:13]=[CH:12][C:9]([CH2:10][NH:11][C:17]([C:19]2[C:28](=[O:29])[C:27]3[C:22](=[CH:23][N:24]=[C:25]([CH2:30][N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)[CH:26]=3)[N:21]([CH3:37])[CH:20]=2)=[O:16])=[CH:8][CH:7]=1

Komponenten

6

Edukt 3

HCID 660364-ChlorobenzylamineHCID 6451240Aluminum(III) ChlorideHCID 22397176HCID 22397176, Verbindung

Produkt 1

HCID 10159541HCID 10159541, VerbindungAusbeute 67 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1140TolueneLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

At 0° C., a solution of 2.0M AlCl3 in toluene (0.14 mL) is added to a solution of 4-chlorobenzylamine (0.044 mL) in CH2Cl2 (5 mL). The compound from ethyl-1-methyl-6-(4-morpholinylmethyl)-4-oxo-1,4-dihydro[1,7]naphthyridine-3-carboxylate (Preparation 46, 0.058 g) is added and the mixture allowed to stir at room temperature for 3 hours at which time the mixture is partitioned between CH2Cl2 (30 mL) and water (30 mL). The organics are dried with Na2SO4, filtered and the solvent evaporated. The remaining solid is chromatographed with MeOH/CH2Cl2 (1-4%) to obtain 0.049 g (67%) of the title compound as an off-white solid. Physical characteristics: MS (ESI+) m/z 427 (M+H).

Aufarbeitung

  1. customis partitioned between CH2Cl2 (30 mL) and water (30 mL)
  2. dry with materialThe organics are dried with Na2SO4
  3. filtrationfiltered
  4. customthe solvent evaporated
  5. customThe remaining solid is chromatographed with MeOH/CH2Cl2 (1-4%)

Quellen und Nachweise

ORD-Eintrag
ord-699ee55737634316b8aa80fec281cb06
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06903097B2

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