Ethanol → 4-(Oxazol-4-yl)aniline

HRID 1070830

Reaktionsgleichung

Reaktionsgleichung von HRID 1070830
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[CH:12][O:13][CH:14]=2)=[CH:6][CH:5]=1)([O-])=O.C(O)C.[H][H]>[C].[Pd].O1CCCC1>[O:13]1[CH:14]=[C:10]([C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=2)[N:11]=[CH:12]1

Komponenten

6

Edukt 3

HCID 702EthanolHCID 145677974-(4-Nitrophenyl)oxazoleHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 223978534-(Oxazol-4-yl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

5% Palladium-carbon powder was added to a suspension of 4-(4-nitrophenyl)-1,3-oxazole in mixture of ethanol and tetrahydrofuran, and the reaction mixture was stirred under 1 atm of hydrogen at ambient temperature for 12 hours. The reaction mixture was filtered through Celite, and the resulting filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography, to obtain [4-(1,3-oxazol-4-yl)phenyl]amine (pale yellow solid). Electron Impact-MS (M)+:160.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe resulting filtrate was concentrated under reduced pressure
  3. customThe resulting crude product was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-95af47684b0e4769aaa2c925c5fec751
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06903125B2

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