1-Iodopropane → HCID 10223420, Verbindung

HRID 1070846

Reaktionsgleichung

Reaktionsgleichung von HRID 1070846
[CH3:1][O:2][C:3](=[O:26])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]2[N:17]=[C:16]([SH:18])[N:15]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:14]=2[CH:25]=1.[CH2:27](I)[CH2:28][CH3:29].C(=O)([O-])O.[K+].C1CC2OCCOCCOC3C(OCCOCCOC2CC1)CCCC3>CN(C)C=O>[CH3:1][O:2][C:3](=[O:26])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]2[N:17]=[C:16]([S:18][CH2:27][CH2:28][CH3:29])[N:15]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:14]=2[CH:25]=1

Komponenten

6

Edukt 4

HCID 336431-IodopropaneHCID 85955Dicyclohexano-18-crown-6HCID 516893Potassium BicarbonateHCID 178500329HCID 178500329, Verbindung

Produkt 1

HCID 10223420HCID 10223420, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

100 mg of 6-[[2-mercapto-1-phenyl-1H-benzimidazol-6-yl]oxy]hexanoic acid methyl ester was dissolved in 2 ml of N,N-dimethylformamide, mixed with 40 μl of propyl iodide, 57 mg of potassium hydrogen carbonate and 10 mg of dicyclohexano-18-crown-6, and the mixture was stirred for 15 hours at 20° C. It was filtered, and the filtrate was concentrated by evaporation in a vacuum. The residue was purified by column chromatography on silica gel. 103 mg was obtained.

Aufarbeitung

  1. filtrationIt was filtered
  2. concentrationthe filtrate was concentrated by evaporation in a vacuum
  3. customThe residue was purified by column chromatography on silica gel
  4. custom103 mg was obtained

Quellen und Nachweise

ORD-Eintrag
ord-b81001596faa4bf7aebe0747d7f86893
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06903126B2

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