HCID 22398528, Verbindung → 4-(5-Fluoro-2-methoxyphenyl)-4-methylpentan-2-one

HRID 1070987

Reaktionsgleichung

Reaktionsgleichung von HRID 1070987
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:20][CH3:21])=[C:6]([C:8]([CH3:19])([CH3:18])[CH2:9][C:10](N2CCOCC2)=[O:11])[CH:7]=1.[CH3:22][Li]>C1COCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:20][CH3:21])=[C:6]([C:8]([CH3:18])([CH3:19])[CH2:9][C:10](=[O:11])[CH3:22])[CH:7]=1

Komponenten

4

Edukt 2

HCID 22398528HCID 22398528, VerbindungHCID 178418348HCID 178418348, Verbindung

Produkt 1

HCID 222849224-(5-Fluoro-2-methoxyphenyl)-4-methylpentan-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 3-(5-fluoro-2-methoxyphenyl)-3-methyl-1-morpholin-4-ylbutan-1-one (0.59 g) in THF (1 mL) stirred under argon and cooled on dry ice/acetone was added methyl lithium (1.4 M in pentane, 2 mL) over 2 minutes. The mixture was stirred for 30 minutes and quenched with EtOH (0.3 mL). The mixture was warmed to room temperature and 1 mL of water was added. The organic phase was separated, washed, dried, filtered, and evaporated. The residue was fractionated over a short column of silica gel (eluent: hexanes-methylene chloride (1:1)) to give the title compound as an oil (0.36 g).

Aufarbeitung

  1. temperaturecooled on dry ice/acetone
  2. customquenched with EtOH (0.3 mL)
  3. addition1 mL of water was added
  4. customThe organic phase was separated
  5. washwashed
  6. customdried
  7. filtrationfiltered
  8. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-3da18985e3cf40d98df5062c234e3bcd
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06903215B2

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