4-Acetylbenzenesulphonamide → HCID 178419020, Verbindung

HRID 10712

Reaktionsgleichung

Reaktionsgleichung von HRID 10712
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH2:13])(=[O:12])=[O:11])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[CH3:14][O:15][C:16]1[C:23]([C:24]2[S:25][CH:26]=[CH:27][CH:28]=2)=[CH:22][C:19]([CH:20]=O)=[C:18]([O:29][CH2:30][C:31]2[NH:35][N:34]=[N:33][N:32]=2)[CH:17]=1>>[CH3:14][O:15][C:16]1[C:23]([C:24]2[S:25][CH:26]=[CH:27][CH:28]=2)=[CH:22][C:19](/[CH:20]=[CH:2]/[C:1]([C:4]2[CH:5]=[CH:6][C:7]([S:10]([NH2:13])(=[O:11])=[O:12])=[CH:8][CH:9]=2)=[O:3])=[C:18]([O:29][CH2:30][C:31]2[NH:32][N:33]=[N:34][N:35]=2)[CH:17]=1

Komponenten

3

Edukt 2

HCID 740654-AcetylbenzenesulphonamideHCID 178418753HCID 178418753, Verbindung

Produkt 1

HCID 178419020HCID 178419020, VerbindungAusbeute 60 %

Versuchsvorschrift

The title compound was prepared by condensing 4-acetyl-benzenesulfonamide (Ex-26A) and 4-methoxy-2-(1H-tetrazol-5-ylmethoxy)-5-thiophen-2-yl-benzaldehyde (Ex-89A) in a similar manner as described in Ex-22. Yellow solid, mp 163–164° C. (dec), 60% yield. 1H-NMR (300 MHz, DMSO-d6) δ 8.31–8.34 (m, 3H), 7.92–8.15 (m, 4H), 7.70 (d, 1H, J=4.0 Hz), 7.54 (m, 3H), 7.15–7.17 (m, 1H), 6.92 (s, 1H), 4.64 (brs, 2H), 4.03 (s, 5H). MS (ESI) m/z=498 ([M+H]+, 100%). Anal. Calcd. for C22H19N5O5S2.1½H2O: C, 50.37; H, 4.23; N, 13.35; S, 12.23. Found: C, 50.48; H, 4.24; N, 12.95; S, 12.35.

Quellen und Nachweise

ORD-Eintrag
ord-6fd8cc18eef045a9bc2899c48626f66d
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094801B2

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