2-(Chloromethyl)aniline hydrochloride → 2-[[(5,6-Dimethyl-1H-benzimidazol-2-yl)thio]methyl]benzenamine

HRID 1071534Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1071534
[CH3:1][C:2]1[C:11]([CH3:12])=[CH:10][C:5]2[N:6]=[C:7]([SH:9])[NH:8][C:4]=2[CH:3]=1.Cl.Cl[CH2:15][C:16]1[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=1[NH2:18]>>[CH3:12][C:11]1[C:2]([CH3:1])=[CH:3][C:4]2[NH:8][C:7]([S:9][CH2:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[NH2:18])=[N:6][C:5]=2[CH:10]=1

Komponenten

3

Edukt 2

HCID 123879412-(Chloromethyl)aniline hydrochlorideHCID 178422342HCID 178422342, Verbindung

Produkt 1

HCID 137541362-[[(5,6-Dimethyl-1H-benzimidazol-2-yl)thio]methyl]benzenamine

Versuchsvorschrift

The title compound was prepared by the method of Example 1 using 2.56 g of 5,6-dimethyl-2-mercaptobenzimidazole instead of 2-mercaptobenzimidazole and 2.56 g of 2-(chloromethyl) aniline hydrochloride instead of 2-(chloromethyl)-N,N-dimethylaniline. Instead of using sodium carbonate in an extraction, the crude precipitate was neutralized with triethylamine in methanol. Trituration of the resultant crude title compound with methanol and diethyl ether gave 2.0 g of analytically pure title compound. Analysis. Calc'd. for C15H15N3S: C, 67.81; H, 6.05; N,14.83; S, 11.31. Found: C, 67.21; H, 6.16; N, 14.50; S, 11.06.

Aufarbeitung

  1. extractionInstead of using sodium carbonate in an extraction

Quellen und Nachweise

ORD-Eintrag
ord-c2ad029856124bdbbcd4aa8131cc1fb6
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06906078B2

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