[O:1]1CCO[CH:2]1[C:6]1[CH:10]=[CH:9][S:8][C:7]=1[CH:11]([CH2:14][CH2:15][CH3:16])[C:12]#[N:13].Cl>CC(C)=O.[Cl-].[Na+].O>[CH:2]([C:6]1[CH:10]=[CH:9][S:8][C:7]=1[CH:11]([CH2:14][CH2:15][CH3:16])[C:12]#[N:13])=[O:1]2.16 g (9.10 mmol) of 2-[3-(1,3-dioxolan-2-yl)-2-thienyl]-4-methylbutyronitrile was dissolved in 40 ml of acetone, 115 ml of 5N HCl was added, and the mixture was heated at 70° C. for 3 minutes. After completion of the reaction, brine was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and evaporated, to give a crude product. The crude product was subjected to 75 g of silica gel (ethyl acetate:hexane=1:2), to give 1.66 g (8.58 mmol, 94.3%) of the title compound as a brown oil.
Wird geladen…
