N-3-(4-pentylphenyl)propylphthalimide → 3-(4-Pentylphenyl)propylamine

HRID 1072716Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1072716
[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][CH2:14][N:15]2C(=O)C3=CC=CC=C3C2=O)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5]>C(O)C.[OH-].[Na+]>[CH2:1]([C:6]1[CH:7]=[CH:8][C:9]([CH2:12][CH2:13][CH2:14][NH2:15])=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

Komponenten

4

Edukt 1

HCID 22387439N-3-(4-pentylphenyl)propylphthalimide

Produkt 1

HCID 223875943-(4-Pentylphenyl)propylamineAusbeute 53 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A solution of N-3-(4-pentylphenyl)propylphthalimide (41.1 g, 123 mmol) and hydrazinemonohydrate (9.0 ml, 185 mmol) in ethanol (300 ml) was refluxed for 3 hours. The reaction mixture was dissolved in 5N aqueous sodium hydroxide and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over magnesium sulfate anhydride, and the organic layer was concentrated to give the object compound as an oily substance. 13.5 g, (yield 53%)

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over magnesium sulfate anhydride
  4. concentrationthe organic layer was concentrated
  5. customto give the object compound as an oily substance

Quellen und Nachweise

ORD-Eintrag
ord-9d5c4dc7bc1a49ae88ad3e74dd16d6ff
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06911468B2

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