Hydrochloric Acid → HCID 10255676, Verbindung

HRID 1072776Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1072776
C[C@@H](N)C1C=CC=CC=1.C[C@@H](N)C1C=CC=CC=1.[N+:19]([CH2:22][C@:23]1([CH2:30][C:31]([OH:33])=[O:32])[CH2:29][C@@H:28]2[C@H:24]1[CH2:25][CH2:26][CH2:27]2)([O-:21])=[O:20].Cl>C(OCC)(=O)C>[N+:19]([CH2:22][C@:23]1([CH2:30][C:31]([OH:33])=[O:32])[CH2:29][C@@H:28]2[C@H:24]1[CH2:25][CH2:26][CH2:27]2)([O-:21])=[O:20]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6431891-Phenethylamine, (+)-HCID 10449552HCID 10449552, Verbindung

Produkt 1

HCID 10255676HCID 10255676, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

The (R)-α-methylbenzylamine salt of the nitro acid from example 2 (5.0 g, 23.4 mmol) was added to a mixture of ethyl acetate (50 ml) and 2M hydrochloric acid (15 ml). The mixture was stirred vigorously for 3-4 minutes and the phases were separated. The organic layer was further washed with 2M hydrochloric acid (15 ml) and demineralised water (15 ml). The organic layer was separated and the solvent was removed in vacuo to give the title compound as a yellow oil, which rapidly crystallised on standing (3.49 g).

Aufarbeitung

  1. customthe phases were separated
  2. washThe organic layer was further washed with 2M hydrochloric acid (15 ml) and demineralised water (15 ml)
  3. customThe organic layer was separated
  4. customthe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-aa8c84ad00e142e4a0e8adf34372da1a
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06911555B2

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