Hydrochloric Acid → HCID 22387751, Verbindung

HRID 1072858Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1072858
Cl.C([O:4][C:5]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[N:11]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[Cl:26])[CH2:10]2)=[O:6])C.[OH-].[Na+].Cl>C(O)C>[ClH:25].[C:5]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[N:11]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[Cl:26])[CH2:10]2)([OH:6])=[O:4]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22388209HCID 22388209, Verbindung

Produkt 1

HCID 22387751HCID 22387751, VerbindungAusbeute 129,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

6-(Ethoxycarbonyl)-3-(2,4-dichlorobenzyl)-3,4-dihydro-2-methylquinazoline hydrochloride (0.68 g) in a mixture of a 10% aqueous sodium hydroxide solution (5 ml) and ethanol (10 ml) was stirred at 60° C. for 1 hr. After standing cool the reaction mixture, concentrated hydrochloric acid (5 ml) was added and the precipitate was collected by filtration. The precipitated was washed with toluene and 2-propanol and dried to give the objective compound (0.41 g) as white crystals.

Aufarbeitung

  1. additionwas added
  2. filtrationthe precipitate was collected by filtration
  3. washThe precipitated was washed with toluene and 2-propanol
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-16f4f57f6295490091dcf07793a69164
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06911469B2

Notizen zur Reaktion

Wird geladen…